Red clover - Trifolium pratense

Monday, November 29, 2010

Just to be Safe: Adverse Reactions, Cautions, Cross Drug and Herb Interactions

Red clover is not recommended during pregnancy
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To date, there have been no documented adverse reactions to red clover consumption (Terzic et al., 2009). However, due to the estrogenic properties of isoflavones, several cautions have been recommended. Individuals with hormone-dependant illnesses should not take red clover – this includes women with uterine, breast or ovarian cancer, fibromyoma and endometriosis, as well as men with prostate cancer (MD idea, 2010.) These recommendations are based on the understanding that isoflavones mimic the effects of estrogen and certain conditions may develop or be exacerbated with elevated levels of estrogen. Red clover consumption is also not recommended in pregnant women, as animal studies on red clover have documented the development of abnormal fetuses (MD idea, 2010.)

Red clover may interact with estrogen-based treatments, such as birth control pills and hormone replacement therapy, to increase estrogens levels beyond recommended limits (UMMC, 2006.) Furthermore it may interfere with the activity of Tamoxifen, a drug used to block estrogen receptors in breast tissue to prevent tumor growth in breast cancer patients (National Cancer Institute, 2010.) Red clover may also interact with anti-coagulant drugs such as Warfarin, Heparin and Ticlopidine, leading to abnormal bleeding and bruising (TrueStar Health, 2010.) Other herbs and supplements that also have anti-coagulant properties, such as garlic, ginger and vitamin E, may act to further exacerbate these potential disorders (UMMC, 2006.)
Alesse, a type of birth control pill
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Tamoxifen, a cancer-fighting drughttp://sandyhutchenscancerprevention.com/wp-content/uploads/2010/02/tamoxifen.jpg
Garlic, a natural anti-coagulant
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